GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats

Hemorrhagic transformation (HT) is a devastating complication for patients with acute ischemic stroke who are treated with tissue plasminogen activator (tPA). It is associated with high morbidity and mortality, but no effective treatments are currently available to reduce HT risk. Therefore, methods...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Neurobiol
Prif Awduron: Wang, Wei, Li, Mingchang, Wang, Yuefei, Li, Qian, Deng, Gang, Wan, Jieru, Yang, Qingwu, Chen, Qianxue, Wang, Jian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909586/
https://ncbi.nlm.nih.gov/pubmed/26671619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-015-9607-2
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