Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue

Arylfluorosulfates have appeared only rarely in the literature and have not been explored as probes for covalent conjugation to proteins, possibly because they were assumed to possess high reactivity, as with other sulfur(VI) halides. However, we find that arylfluorosulfates become reactive only und...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Chen, Wentao, Dong, Jiajia, Plate, Lars, Mortenson, David E., Brighty, Gabriel J., Li, Suhua, Liu, Yu, Galmozzi, Andrea, Lee, Peter S., Hulce, Jonathan J., Cravatt, Benjamin F., Saez, Enrique, Powers, Evan T., Wilson, Ian A., Sharpless, K. Barry, Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909538/
https://ncbi.nlm.nih.gov/pubmed/27191344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02960
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