BMP2, a key to uncover luminal breast cancer origin linked to pollutant effects on epithelial stem cells niche

Chronic exposure of epithelial cells to high levels of bone morphogenetic protein 2 (BMP2) has recently been demonstrated to initiate stem cell transformation toward a luminal tumor-like phenotype through a BMP2–BMPR1B-dependent mechanism. Carcinogen-driven deregulation of the stem cell niche could...

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Udgivet i:Mol Cell Oncol
Main Authors: Chapellier, Marion, Maguer-Satta, Véronique
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909443/
https://ncbi.nlm.nih.gov/pubmed/27314065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1026527
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