Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer

Currently, no therapeutic options exist for castration-resistant prostate cancer (CRPC) patients who have developed resistance to the second generation anti-androgen receptor (AR) axis therapy. Here we report that co-deletion of Pten and p53 in murine prostate epithelium, often observed in human CRP...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wang, Lei, Wang, Ji, Xiong, Hua, Wu, Fengxia, Lan, Tian, Zhang, Yingjie, Guo, Xiaolan, Wang, Huanan, Saleem, Mohammad, Jiang, Cheng, Lu, Junxuan, Deng, Yibin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909365/
https://ncbi.nlm.nih.gov/pubmed/27322458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.03.022
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