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Optogenetic Control of Calcium Oscillation Waveform Defines NFAT as an Integrator of Calcium Load
It is known that the calcium-dependent transcription factor NFAT initiates transcription in response to pulsatile loads of calcium signal. However, the relative contributions of calcium oscillation frequency, amplitude, and duty cycle to transcriptional activity remain unclear. Here, we engineer HeL...
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| Udgivet i: | Cell Syst |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909256/ https://ncbi.nlm.nih.gov/pubmed/27135540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.03.010 |
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