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Optogenetic Control of Voltage‐Gated Calcium Channels

Voltage‐gated Ca(2+) (Ca(V)) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca(V) channel modulators, to enable photo‐tunable modulation of Ca(V) ch...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Ma, Guolin, Liu, Jindou, Ke, Yuepeng, Liu, Xin, Li, Minyong, Wang, Fen, Han, Gang, Huang, Yun, Wang, Youjun, Zhou, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032918/
https://ncbi.nlm.nih.gov/pubmed/29569306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713080
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