Endoplasmic Reticulum Chaperone Gp96 in Macrophages is Essential for Protective Immunity during Gram-negative Pneumonia

Klebsiella pneumoniae is among the most common gram-negative bacteria that cause pneumonia. Gp96 is an endoplasmic reticulum chaperone that is essential for the trafficking and function of Toll-like receptors (TLRs) and integrins. To determine the role of gp96 in myeloid cells in host defence during...

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Veröffentlicht in:J Pathol
Hauptverfasser: Anas, Adam A., de Vos, Alex F., Hoogendijk, Arie J., van Lieshout, Miriam H.P., van Heijst, Jeroen W.J., Florquin, Sandrine, Li, Zihai, van ’t Veer, Cornelis, van der Poll, Tom
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909154/
https://ncbi.nlm.nih.gov/pubmed/26365983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4637
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