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PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection
The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized patients.(1,2) Here we show that the mitochondrial biogenesis regulator, PGC1α,(3,4)...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909121/ https://ncbi.nlm.nih.gov/pubmed/26982719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17184 |
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