TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

Because injured mitochondria can accelerate cell death through the elaboration of oxidative free radicals and other mediators, it is striking that proliferator γ coactivator 1-α (PGC1α), a stimulator of increased mitochondrial abundance, protects stressed renal cells instead of potentiating injury....

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Publicado en:JCI Insight
Main Authors: Lynch, Matthew R., Tran, Mei T., Ralto, Kenneth M., Zsengeller, Zsuzsanna K., Raman, Vinod, Bhasin, Swati S., Sun, Nuo, Chen, Xiuying, Brown, Daniel, Rovira, Ilsa I., Taguchi, Kensei, Brooks, Craig R., Stillman, Isaac E., Bhasin, Manoj K., Finkel, Toren, Parikh, Samir M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538327/
https://ncbi.nlm.nih.gov/pubmed/30870143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126749
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