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Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function
Retroviral integrase (IN) catalyzes the integration of viral DNA (vDNA) into host target (tDNA), which is an essential step in the lifecycle of all retroviruses(1). Prior structural characterization of IN-vDNA complexes, or intasomes, from the spumavirus prototype foamy virus (PFV) revealed a functi...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4908968/ https://ncbi.nlm.nih.gov/pubmed/26887496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16955 |
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