Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function

Retroviral integrase (IN) catalyzes the integration of viral DNA (vDNA) into host target (tDNA), which is an essential step in the lifecycle of all retroviruses(1). Prior structural characterization of IN-vDNA complexes, or intasomes, from the spumavirus prototype foamy virus (PFV) revealed a functi...

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Udgivet i:Nature
Main Authors: Ballandras-Colas, Allison, Brown, Monica, Cook, Nicola J., Dewdney, Tamaria G., Demeler, Borries, Cherepanov, Peter, Lyumkis, Dmitry, Engelman, Alan N.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908968/
https://ncbi.nlm.nih.gov/pubmed/26887496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16955
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