Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

Aberrant neuronal translation is implicated in the etiology of numerous brain disorders. Although mTORC1-p70 ribosomal S6 kinase 1 (S6K1) signaling is critical for translational control, pharmacological manipulation in vivo has targeted exclusively mTORC1 due to the paucity of specific inhibitors to...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Bhattacharya, Aditi, Mamcarz, Maggie, Mullins, Caitlin, Choudhury, Ayesha, Boyle, Robert G, Smith, Daniel G, Walker, David W, Klann, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908636/
https://ncbi.nlm.nih.gov/pubmed/26708105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.369
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