Engineering vanilloid-sensitivity into the rat TRPV2 channel

The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the threshold for heat activation is extremely high (&...

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Bibliographic Details
Published in:eLife
Main Authors: Zhang, Feng, Hanson, Sonya M, Jara-Oseguera, Andres, Krepkiy, Dmitriy, Bae, Chanhyung, Pearce, Larry V, Blumberg, Peter M, Newstead, Simon, Swartz, Kenton J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907692/
https://ncbi.nlm.nih.gov/pubmed/27177419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16409
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