Engineering vanilloid-sensitivity into the rat TRPV2 channel

The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the threshold for heat activation is extremely high (&...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Zhang, Feng, Hanson, Sonya M, Jara-Oseguera, Andres, Krepkiy, Dmitriy, Bae, Chanhyung, Pearce, Larry V, Blumberg, Peter M, Newstead, Simon, Swartz, Kenton J
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907692/
https://ncbi.nlm.nih.gov/pubmed/27177419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16409
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