Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colo...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Chellappa, Karthikeyani, Deol, Poonamjot, Evans, Jane R, Vuong, Linh M, Chen, Gang, Briançon, Nadege, Bolotin, Eugene, Lytle, Christian, Nair, Meera G, Sladek, Frances M
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907689/
https://ncbi.nlm.nih.gov/pubmed/27166517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10903
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