Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer

Src tyrosine kinase has long been implicated in colon cancer but much remains to be learned about its substrates. The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) has just recently been implicated in colon cancer but its role is poorly defined. Here we show that c-Src phosphorylates human H...

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Detalhes bibliográficos
Main Authors: Chellappa, Karthikeyani, Jankova, Lucy, Schnabl, Jake M., Pan, Songqin, Brelivet, Yann, Fung, Caroline L-S., Chan, Charles, Dent, Owen F., Clarke, Stephen J., Robertson, Graham R., Sladek, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289305/
https://ncbi.nlm.nih.gov/pubmed/22308320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106799109
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