Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colo...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chellappa, Karthikeyani, Deol, Poonamjot, Evans, Jane R, Vuong, Linh M, Chen, Gang, Briançon, Nadege, Bolotin, Eugene, Lytle, Christian, Nair, Meera G, Sladek, Frances M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907689/
https://ncbi.nlm.nih.gov/pubmed/27166517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10903
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