Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer

Src tyrosine kinase has long been implicated in colon cancer but much remains to be learned about its substrates. The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) has just recently been implicated in colon cancer but its role is poorly defined. Here we show that c-Src phosphorylates human H...

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Bibliografiske detaljer
Main Authors: Chellappa, Karthikeyani, Jankova, Lucy, Schnabl, Jake M., Pan, Songqin, Brelivet, Yann, Fung, Caroline L-S., Chan, Charles, Dent, Owen F., Clarke, Stephen J., Robertson, Graham R., Sladek, Frances M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289305/
https://ncbi.nlm.nih.gov/pubmed/22308320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106799109
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