Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro

Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme that catalyzes the metabolism of a great number of therapeutic drugs. Up to now, >100 allelic variants of CYP2D6 have been reported. Recently, we identified 22 novel variants in the Chinese population in these variants. The purpose of th...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Wang, Zhe, Wang, Li, Xu, Ren-ai, Zhan, Yun-yun, Huang, Cheng-ke, Dai, Da-peng, Cai, Jian-ping, Hu, Guo-xin
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907640/
https://ncbi.nlm.nih.gov/pubmed/27354764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S106175
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