Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease

A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 10(4) CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoid diagnosis -TD-) 6–9 days post-challenge. TD wa...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Toapanta, Franklin R., Bernal, Paula J., Fresnay, Stephanie, Magder, Laurence S., Darton, Thomas C., Jones, Claire, Waddington, Claire S., Blohmke, Christoph J., Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907489/
https://ncbi.nlm.nih.gov/pubmed/27300136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004766
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