Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease

A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 10(4) CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoid diagnosis -TD-) 6–9 days post-challenge. TD wa...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Toapanta, Franklin R., Bernal, Paula J., Fresnay, Stephanie, Magder, Laurence S., Darton, Thomas C., Jones, Claire, Waddington, Claire S., Blohmke, Christoph J., Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907489/
https://ncbi.nlm.nih.gov/pubmed/27300136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004766
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