Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

BACKGROUND: Typhoid fever, caused by the human-restricted organism Salmonella Typhi (S. Typhi), is a major public health problem worldwide. Development of novel vaccines remains imperative, but is hampered by an incomplete understanding of the immune responses that correlate with protection. METHODS...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Fresnay, Stephanie, McArthur, Monica A., Magder, Laurence, Darton, Thomas C., Jones, Claire, Waddington, Claire S., Blohmke, Christoph J., Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772330/
https://ncbi.nlm.nih.gov/pubmed/26928826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0819-7
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