PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia

Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and humans. In agreement with previous work on rIL-10, we report...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Chan, Ivan H., Van Hoof, Dennis, Abramova, Marina, Bilardello, Melissa, Mar, Elliot, Jorgensen, Brett, McCauley, Scott, Bal, Harminder, Oft, Martin, Van Vlasselaer, Peter, Mumm, John B.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907428/
https://ncbi.nlm.nih.gov/pubmed/27299860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156229
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