PEG-rIL-10 treatment decreases FoxP3(+) Tregs despite upregulation of intratumoral IDO

IL-10 has been classically defined as a broad-spectrum immunosuppressant and is thought to facilitate the development of regulatory CD4(+) T cells. IL-10 is believed to represent one of the major suppressive factors secreted by IDO(+)FoxP3(+)CD4(+) T(regs). Contrary to this view, we have previously...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Chan, Ivan H., Wu, Victoria, Bilardello, Melissa, Jorgenson, Brett, Bal, Harminder, McCauley, Scott, Van Vlasselaer, Peter, Mumm, John B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
MIATA Compliant Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006922/
https://ncbi.nlm.nih.gov/pubmed/27622052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1197458
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