Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

Andes virus (ANDV) is a human-pathogenic hantavirus. Hantaviruses presumably initiate their mRNA synthesis by using cap structures derived from host cell mRNAs, a mechanism called cap-snatching. A signature for a cap-snatching endonuclease is present in the N terminus of hantavirus L proteins. In th...

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Publicat a:PLoS Pathog
Autors principals: Fernández-García, Yaiza, Reguera, Juan, Busch, Carola, Witte, Gregor, Sánchez-Ramos, Oliberto, Betzel, Christian, Cusack, Stephen, Günther, Stephan, Reindl, Sophia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907427/
https://ncbi.nlm.nih.gov/pubmed/27300328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005635
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