Two mutations in the beta-globin polyadenylylation signal reveal extended transcripts and new RNA polyadenylylation sites.

Two mutations in the beta-globin poly(A) signal were identified in Israeli patients with beta +-thalassemia by sequence analysis following PCR. One is a point mutation (AATAAA----AATAAG) and the other is a 5-base-pair deletion (AATAAA----A----). The mutant genes were used to investigate the function...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rund, D, Dowling, C, Najjar, K, Rachmilewitz, E A, Kazazian, H H, Oppenheim, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1374896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4324
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