Two mutations in the beta-globin polyadenylylation signal reveal extended transcripts and new RNA polyadenylylation sites.

Two mutations in the beta-globin poly(A) signal were identified in Israeli patients with beta +-thalassemia by sequence analysis following PCR. One is a point mutation (AATAAA----AATAAG) and the other is a 5-base-pair deletion (AATAAA----A----). The mutant genes were used to investigate the function...

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Библиографические подробности
Главные авторы: Rund, D, Dowling, C, Najjar, K, Rachmilewitz, E A, Kazazian, H H, Oppenheim, A
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC49074/
https://ncbi.nlm.nih.gov/pubmed/1374896
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