Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

BACKGROUND: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, which is characterized by inflammation of synovial joints leading to the destruction of cartilage and bone. Infiltrating mast cells can be found within the inflamed synovial tissue, however their role in disease pathogenes...

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Publicat a:Arthritis Res Ther
Autors principals: van der Velden, Daniël, Lagraauw, H. Maxime, Wezel, Anouk, Launay, Pierre, Kuiper, Johan, Huizinga, Tom W. J., Toes, René E. M., Bot, Ilze, Stoop, Jeroen N.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907027/
https://ncbi.nlm.nih.gov/pubmed/27296719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1036-8
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