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Identification and reconstitution of the polyketide synthases responsible for biosynthesis of the anti-malarial agent, cladosporin
The anti-malarial agent cladosporin is a nanomolar inhibitor of Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both blood and liver stage infection. Cladosporin can be isolated from the fungus Cladosporium cladosporioides, where it was believed to be biosynthesized by a h...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4906947/ https://ncbi.nlm.nih.gov/pubmed/26783060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509345 |
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