Human Dopamine β-Hydroxylase Promoter Variant Alters Transcription in Chromaffin Cells, Enzyme Secretion, and Blood Pressure

BACKGROUND: Dopamine β-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Here, we characterized a DBH promoter polymorphism (C-2073T; rs1989787; minor allele frequency ∼16%) that influences not only gene transcription but also enzyme...

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Pubblicato in:Am J Hypertens
Autori principali: Chen, Yuqing, Zhang, Kuixing, Wen, Gen, Rao, Fangwen, Sanchez, Amber P., Wang, Lei, Rodriguez-Flores, Juan L., Mahata, Manjula, Mahata, Sushil K., Waalen, Jill, Ziegler, Michael G., Hamilton, Bruce A., O'Connor, Daniel T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Original Contributions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906639/
https://ncbi.nlm.nih.gov/pubmed/20814407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajh.2010.186
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