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Human Dopamine β-Hydroxylase Promoter Variant Alters Transcription in Chromaffin Cells, Enzyme Secretion, and Blood Pressure
BACKGROUND: Dopamine β-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Here, we characterized a DBH promoter polymorphism (C-2073T; rs1989787; minor allele frequency ∼16%) that influences not only gene transcription but also enzyme...
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| Publicado en: | Am J Hypertens |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4906639/ https://ncbi.nlm.nih.gov/pubmed/20814407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajh.2010.186 |
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