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Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wijdeven, Ruud H., Janssen, Hans, Nahidiazar, Leila, Janssen, Lennert, Jalink, Kees, Berlin, Ilana, Neefjes, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906411/
https://ncbi.nlm.nih.gov/pubmed/27283760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11808
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