Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity

Apoptosis of islet β cells is a primary pathogenic feature of type 2 diabetes, and ER stress and mitochondrial dysfunction play important roles in this process. Previous research has shown that prostate apoptosis response-4 (Par-4)/NF-κB induces cancer cell apoptosis through endoplasmic reticulum (E...

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Veröffentlicht in:J Diabetes Res
Hauptverfasser: QiNan, Wu, XiaGuang, Gan, XiaoTian, Lei, WuQuan, Deng, Ling, Zhang, Bing, Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906207/
https://ncbi.nlm.nih.gov/pubmed/27340675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4692478
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