Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor

Glycine receptors (GlyRs) mediate inhibitory neurotransmission and are targets for alcohols and anesthetics in brain. GlyR transmembrane (TM) domains contain critical residues for alcohol/anesthetic action: amino acid A288 in TM3 forms crosslinks with TM1 (I229) in the adjacent subunit as well as TM...

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Udgivet i:Front Mol Neurosci
Main Authors: McCracken, Mandy L., Gorini, Giorgio, McCracken, Lindsay M., Mayfield, R. Dayne, Harris, R. Adron, Trudell, James R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906044/
https://ncbi.nlm.nih.gov/pubmed/27378846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00045
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