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Inhibition of Cerebral Vascular Inflammation by Brain Endothelium-Targeted Oligodeoxynucleotide Complex

The present study generated a novel DNA complex to specifically target endothelial NF-κB to inhibit cerebral vascular inflammation. This DNA complex (GS24-NFκB) contains a DNA decoy which inhibits NF-κB activity, and a DNA aptamer (GS-24), a ligand of transferrin receptor (TfR), which allows for tar...

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Dades bibliogràfiques
Publicat a:Neuroscience
Autors principals: Hu, Jing, Al-Waili, Daniah, Hassan, Aishlin, Fan, Guo-Chang, Xin, Mei, Hao, Jiukuan
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905813/
https://ncbi.nlm.nih.gov/pubmed/27132231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.04.033
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