YAP/TAZ-CDC42 signaling regulates vascular tip cell migration

Angiogenesis and vascular remodeling are essential for the establishment of vascular networks during organogenesis. Here we show that the Hippo signaling pathway effectors YAP and TAZ are required, in a gene dosage-dependent manner, for the proliferation and migration of vascular endothelial cells (...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sakabe, Masahide, Fan, Jieqing, Odaka, Yoshinobu, Liu, Ning, Hassan, Aishlin, Duan, Xin, Stump, Paige, Byerly, Luke, Donaldson, Megan, Hao, Jiukuan, Fruttiger, Marcus, Lu, Qing Richard, Zheng, Yi, Lang, Richard A., Xin, Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642684/
https://ncbi.nlm.nih.gov/pubmed/28973878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704030114
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