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More challenges ahead—metabolic heterogeneity of pancreatic cancer stem cells
Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified...
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| Udgivet i: | Mol Cell Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905405/ https://ncbi.nlm.nih.gov/pubmed/27308630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1105353 |
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