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Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell populations and are highly resistant to standard chemotherapy. Here we demonstrate that metformin selectively ablated pancrea...

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Bibliografische gegevens
Hoofdauteurs: Lonardo, Enza, Cioffi, Michele, Sancho, Patricia, Sanchez-Ripoll, Yolanda, Trabulo, Sara Maria, Dorado, Jorge, Balic, Anamaria, Hidalgo, Manuel, Heeschen, Christopher
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799760/
https://ncbi.nlm.nih.gov/pubmed/24204632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076518
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