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G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
We identify Gα(s) as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gα(s) not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP i...
Gardado en:
| Publicado en: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905062/ https://ncbi.nlm.nih.gov/pubmed/27308425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723556.2014.975070 |
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