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Aneuploidy and proteotoxic stress in cancer

Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuplo...

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Publicat a:Mol Cell Oncol
Autors principals: Donnelly, Neysan, Storchová, Zuzana
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904904/
https://ncbi.nlm.nih.gov/pubmed/27308438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723556.2014.976491
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