Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7

[Image: see text] The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16(INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Ren, Chunyan, Smith, Steven G., Yap, Kyoko, Li, SiDe, Li, Jiaojie, Mezei, Mihaly, Rodriguez, Yoel, Vincek, Adam, Aguilo, Francesca, Walsh, Martin J., Zhou, Ming-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904266/
https://ncbi.nlm.nih.gov/pubmed/27326334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00042
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