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The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes

Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by T cell-mediated destruction of the insulin-producing pancreatic β cells. A combination of genetic and environmental factors eventually leads to the loss of functional β cells mass and hyperglycemia. Both innate and adapti...

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Detalhes bibliográficos
Publicado no:J Autoimmun
Main Authors: Tai, Ningwen, Wong, F. Susan, Wen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4903935/
https://ncbi.nlm.nih.gov/pubmed/27021275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.03.006
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