MB-108 EXPRESSION OF TROPOMYOSIN RECEPTOR KINASE C (TrkC) HAS NO MAJOR IMPACT ON THE RESPONSE TO THERAPY OF MEDULLOBLASTOMA IN VITRO AND IN A CLINICAL PATIENT COHORT

Eitemau Tebyg

• c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients
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• Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.
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• TrkC-Targeted Kinase Inhibitors And PROTACs
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• RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells
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• TrkC promotes colorectal cancer growth and metastasis
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