Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE

Cores of aromatic polyketides are essential for their biological activities. Most type II polyketide synthases (PKSs) biosynthesize these core structures involving the minimal PKS, a PKS-associated ketoreductase (KR) and aromatases/cyclases (ARO/CYCs). Oxygenases (OXYs) are rarely involved. BE-7585A...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Jackson, David R., Yu, Xia, Wang, Guojung, Patel, Avinash, Calveras, Jordi, Barajas, Jesus, Sasaki, Eita, Metsä-Ketelä, Mikko, Liu, Hung-wen, Rohr, Jürgen, Tsai, Shiou-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902875/
https://ncbi.nlm.nih.gov/pubmed/26813028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00913
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