Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE

Cores of aromatic polyketides are essential for their biological activities. Most type II polyketide synthases (PKSs) biosynthesize these core structures involving the minimal PKS, a PKS-associated ketoreductase (KR) and aromatases/cyclases (ARO/CYCs). Oxygenases (OXYs) are rarely involved. BE-7585A...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Jackson, David R., Yu, Xia, Wang, Guojung, Patel, Avinash, Calveras, Jordi, Barajas, Jesus, Sasaki, Eita, Metsä-Ketelä, Mikko, Liu, Hung-wen, Rohr, Jürgen, Tsai, Shiou-Chuan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902875/
https://ncbi.nlm.nih.gov/pubmed/26813028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00913
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