AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction

The Ca(2+)-responsive phosphatase calcineurin/ protein phosphatase 2B dephosphorylates the transcription factor NFATc3. In the myocardium activation of NFATc3 down-regulates the expression of voltage-gated K(+) (K(v)) channels after myocardial infarction (MI). This prolongs action potential duration...

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Udgivet i:Cell Signal
Main Authors: Nieves-Cintrón, Madeline, Hirenallur-S, Dinesh, Nygren, Patrick J., Hinke, Simon A., Dell’Acqua, Mark L, Langeberg, Lorene K., Navedo, Manuel, Santana, Luis F., Scott, John D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902329/
https://ncbi.nlm.nih.gov/pubmed/26724383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.12.015
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