Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder

Por Nygren, Patrick J., Scott, John D.
Publicado no Front Pharmacol (2015)

Regulation of the phosphatase PP2B by protein–protein interactions

Por Nygren, Patrick J., Scott, John D.
Publicado no Biochem Soc Trans (2016)

Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220

Por Whiting, Jennifer L., Nygren, Patrick J., Tunquist, Brian J., Langeberg, Lorene K., Seternes, Ole-Morten, Scott, John D.
Publicado no J Biol Chem (2015)

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex

Por Gold, Matthew G., Stengel, Florian, Nygren, Patrick J., Weisbrod, Chad R., Bruce, James E., Robinson, Carol V., Barford, David, Scott, John D.
Publicado em 2011

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction

Por Nieves-Cintrón, Madeline, Hirenallur-S, Dinesh, Nygren, Patrick J., Hinke, Simon A., Dell’Acqua, Mark L, Langeberg, Lorene K., Navedo, Manuel, Santana, Luis F., Scott, John D.
Publicado no Cell Signal (2015)

Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Por Nygren, Patrick J, Mehta, Sohum, Schweppe, Devin K, Langeberg, Lorene K, Whiting, Jennifer L, Weisbrod, Chad R, Bruce, James E, Zhang, Jin, Veesler, David, Scott, John D
Publicado no eLife (2017)

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors

Por Samelson, Bret K., Gore, Bryan B., Whiting, Jennifer L., Nygren, Patrick J., Purkey, Alicia M., Colledge, Marcie, Langeberg, Lorene K., Dell'Acqua, Mark L., Zweifel, Larry S., Scott, John D.
Publicado no J Biol Chem (2015)

Local protein kinase A action proceeds through intact holoenzymes

Por Smith, F. Donelson, Esseltine, Jessica L., Nygren, Patrick J., Veesler, David, Byrne, Dominic P., Vonderach, Matthias, Strashnov, Ilya, Eyers, Claire E., Eyers, Patrick A., Langeberg, Lorene K., Scott, John D.
Publicado no Science (2017)

Anchored phosphatases modulate glucose homeostasis

Por Hinke, Simon A, Navedo, Manuel F, Ulman, Allison, Whiting, Jennifer L, Nygren, Patrick J, Tian, Geng, Jimenez-Caliani, Antonio J, Langeberg, Lorene K, Cirulli, Vincenzo, Tengholm, Anders, Dell'Acqua, Mark L, Santana, L Fernando, Scott, John D
Publicado em 2012

Anchored phosphatases modulate glucose homeostasis

Por Hinke, Simon A, Navedo, Manuel F, Ulman, Allison, Whiting, Jennifer L, Nygren, Patrick J, Tian, Geng, Jimenez-Caliani, Antonio J, Langeberg, Lorene K, Cirulli, Vincenzo, Tengholm, Anders, Dell'Acqua, Mark L, Fernando Santana, L, Scott, John D
Publicado em 2012

AKAP150 Contributes to Enhanced Vascular Tone by Facilitating BK(Ca) Channel Remodeling in Hyperglycemia and Diabetes

Por Nystoriak, Matthew A., Nieves-Cintrón, Madeline, Nygren, Patrick J., Hinke, Simon A., Nichols, C. Blake, Chen, Chao-Yin, Puglisi, Jose L., Izu, Leighton T., Bers, Donald M., Dell’Acqua, Mark L., Scott, John D., Santana, Luis F., Navedo, Manuel F.
Publicado em 2013