Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill

It has been hypothesized that continuously releasing drug molecules into the tumor over an extended period of time may significantly improve the chemotherapeutic efficacy by overcoming physical transport limitations of conventional bolus drug treatment. In this paper, we present a generalized space-...

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Publicado en:PLoS Comput Biol
Autores principales: Wang, Zhihui, Kerketta, Romica, Chuang, Yao-Li, Dogra, Prashant, Butner, Joseph D., Brocato, Terisse A., Day, Armin, Xu, Rong, Shen, Haifa, Simbawa, Eman, AL-Fhaid, A. S., Mahmoud, S. R., Curley, Steven A., Ferrari, Mauro, Koay, Eugene J., Cristini, Vittorio
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902302/
https://ncbi.nlm.nih.gov/pubmed/27286441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004969
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