Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill

It has been hypothesized that continuously releasing drug molecules into the tumor over an extended period of time may significantly improve the chemotherapeutic efficacy by overcoming physical transport limitations of conventional bolus drug treatment. In this paper, we present a generalized space-...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Wang, Zhihui, Kerketta, Romica, Chuang, Yao-Li, Dogra, Prashant, Butner, Joseph D., Brocato, Terisse A., Day, Armin, Xu, Rong, Shen, Haifa, Simbawa, Eman, AL-Fhaid, A. S., Mahmoud, S. R., Curley, Steven A., Ferrari, Mauro, Koay, Eugene J., Cristini, Vittorio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902302/
https://ncbi.nlm.nih.gov/pubmed/27286441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004969
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