Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill

It has been hypothesized that continuously releasing drug molecules into the tumor over an extended period of time may significantly improve the chemotherapeutic efficacy by overcoming physical transport limitations of conventional bolus drug treatment. In this paper, we present a generalized space-...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Wang, Zhihui, Kerketta, Romica, Chuang, Yao-Li, Dogra, Prashant, Butner, Joseph D., Brocato, Terisse A., Day, Armin, Xu, Rong, Shen, Haifa, Simbawa, Eman, AL-Fhaid, A. S., Mahmoud, S. R., Curley, Steven A., Ferrari, Mauro, Koay, Eugene J., Cristini, Vittorio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902302/
https://ncbi.nlm.nih.gov/pubmed/27286441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004969
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