Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill

It has been hypothesized that continuously releasing drug molecules into the tumor over an extended period of time may significantly improve the chemotherapeutic efficacy by overcoming physical transport limitations of conventional bolus drug treatment. In this paper, we present a generalized space-...

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Publicat a:PLoS Comput Biol
Autors principals: Wang, Zhihui, Kerketta, Romica, Chuang, Yao-Li, Dogra, Prashant, Butner, Joseph D., Brocato, Terisse A., Day, Armin, Xu, Rong, Shen, Haifa, Simbawa, Eman, AL-Fhaid, A. S., Mahmoud, S. R., Curley, Steven A., Ferrari, Mauro, Koay, Eugene J., Cristini, Vittorio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902302/
https://ncbi.nlm.nih.gov/pubmed/27286441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004969
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