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Esterase-sensitive prodrugs with tunable release rates and direct generation of hydrogen sulfide()
Prodrugs that release hydrogen sulfide upon esterase-mediated cleavage of an ester group followed by lactonization are described herein. By modifying the ester group and thus its susceptibility to esterase, and structural features critical to the lactonization rate, H(2)S release rates can be tuned....
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| Publicado no: | Angew Chem Int Ed Engl |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4902284/ https://ncbi.nlm.nih.gov/pubmed/26822005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201511244 |
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